What is Strand resection?
From Wikipedia, the free encyclopedia. DNA end resection, also called 5′–3′ degradation, is a biochemical process where the blunt end of a section of double-stranded DNA (dsDNA) is modified by cutting away some nucleotides from the 5′ end to produce a 3′ single-stranded sequence.
What is DSB resection?
When DSBs occur, a process termed DNA end resection is activated, which catalyzes the nucleolytic degradation of the broken ends in the 5′ to the 3′ direction [9], [10]. The resulting 3′ single-stranded DNA (ssDNA) then provides a platform for the recruitment of proteins that participate in HR repair [9], [10], [11].
What are the 2 types of DNA?
There are two types of DNA in the cell – autosomal DNA and mitochondrial DNA. Autosomal DNA (also called nuclear DNA) is packaged into 22 paired chromosomes. In each pair of autosomes, one was inherited from the mother and one was inherited from the father.
What is DNA end resection?
DNA end resection, also called 5′–3′ degradation, is a biochemical process where the blunt end of a section of double-stranded DNA is modified by cutting away some nucleotides from the 5′ end to produce a 3′ single-stranded sequence.
What does resection mean in biology?
Position resection, a means of establishing a location by measuring angles only to known points Resection (free stationing), a means of establishing a position and orientation of a total station by measuring angles and distances to known points DNA end resection, the process of cutting away the 5′ side of a blunt end of double-stranded DNA
What is DNA repair?
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day.
How does the nucleotide excision repair pathway work?
This relaxation allows other proteins in the nucleotide excision repair pathway to enter the chromatin and repair UV-induced cyclobutane pyrimidine dimer damages. After rapid chromatin remodeling, cell cycle checkpoints are activated to allow DNA repair to occur before the cell cycle progresses.