What is the COX-2 gene?

Cyclooxygenase-2 (COX-2) gene overexpression is suggested to play important roles in colorectal tumorigenesis. Epidemiological studies revealed that nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and sulindac, which inhibit COX activity, reduce colorectal cancer mortality.

What is the COX-2 pathway?

The COX-2 pathway is a key mediator of the inflammatory response to tissue damage and other stimuli. Given that our results suggest an important role for COX-2 during the early stages of muscle regeneration, we also examined the inflammatory response after muscle injury in SC-236-treated and COX-2−/− mice.

What does COX-2 regulate?

Cyclooxygenase 2 (COX2) is frequently expressed in cancer and is involved in the synthesis of prostaglandin E(2) which can promote tumor growth by binding its receptors and activating signaling pathways which regulate cell proliferation, migration, apoptosis, and angiogenesis.

What is PTGS2 gene?

PTGS2 (Prostaglandin-Endoperoxide Synthase 2) is a Protein Coding gene. Diseases associated with PTGS2 include Gastric Ulcer and Stomach Disease. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Signaling mediated by p38-alpha and p38-beta.

Where are COX-2 receptors found?

COX-1 was found in blood vessels, interstitial cells, smooth muscle cells, platelets and mesothelial cells. In contrast, COX-2 was found predominantly in the parenchymal cells of many tissues, with few exceptions, for example the heart.

What are COX-1 and COX-2 pathways?

Cyclooxygenases (COX-1 and COX-2) are key enzymes in the conversion of arachidonic acid to prostaglandins and other lipid mediators. Because it can be induced by inflammatory stimuli, COX-2 has been classically considered as the most appropriate target for anti-inflammatory drugs.

What do COX-2 enzymes do?

Cox-2 is the inducible form of cyclo-oxygenase and catalyzes the conversion of arachidonic acid to prostaglandins. Cox-2 is expressed by inflammatory cells, such as macrophages, and can be induced by TNF and EGF.

What are COX-2 inhibitors?

COX-2 inhibitors (such as Celebrex and Bextra) are a type of NSAID and are the most commonly prescribed drugs for arthritis. COX-2 inhibitors are also prescribed for many forms of back pain.

What are Cox-2 inhibitors used for?

What is COX in pharmacology?

Cyclooxygenase (COX) is a rate-limiting enzyme involved in the conversion of arachidonic acid to prostaglandin H2, which is the precursor of several molecules, including prostaglandins, prostacyclin, and thromboxanes.

What are COX-2 selective drugs?

COX-2 Selective (includes Bextra, Celebrex, and Vioxx) and Non-Selective Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)