What is cyclodextrin used for?
In the pharmaceutical industry, cyclodextrins have mainly been used as complexing agents to increase the aqueous solubility of active substances poorly soluble in water, in order to increase their bioavailability and to improve stability.
What is a cyclodextrin complex?
Cyclodextrin (CD) are cyclic oligosaccharides consisting of glucopyranosyl units linked by α-(1,4) bonds. The cyclodextrin molecules have a unique structure with a hydrophobic cavity and a hydrophilic surface which can form inclusion complex with a wide variety of guests.
Is cyclodextrin a drug?
Cyclodextrins are a family of cyclic oligosaccharides with widespread usage in medicine, industry and basic sciences owing to their ability to solubilize and stabilize guest compounds. In medicine, cyclodextrins primarily act as a complexing vehicle and consequently serve as powerful drug delivery agents.
How do you get cyclodextrin?
Cyclodextrins are produced from starch by enzymatic conversion. They are used in food, pharmaceutical, drug delivery, and chemical industries, as well as agriculture and environmental engineering. Cyclodextrins are composed of 5 or more α-D-glucopyranoside units linked 1->4, as in amylose (a fragment of starch).
What are the health benefits of cyclodextrin?
Based on these properties, cyclodextrins are dietary fibers useful for controlling the body weight and blood lipid profile. They are prebiotics, improve the intestinal microflora by selective proliferation of bifidobacteria.
Where is cyclodextrin found?
Cyclodextrins can be found in nature. Some bacteria (e.g. Bacillus macerans) produce CDs from starch by enzymatic process for their energy storage. This process is mimicked by the industry using cyclodextrin glycosyltransferase enzyme and starch (corn, potato, manioc, etc) as raw material.
Who manufactures cyclodextrin?
WACKER
WACKER is the only company in the world to produce all three naturally occurring cyclodextrins, marketing them under the trade names CAVAMAX® W6 (α-cyclodextrin), W7 (β-cyclodextrin) and W8 (γ-cyclodextrin).
Where can I get cyclodextrin?
Is cyclodextrin a statin?
Cardiovascular disease (CVD) is a leading cause of death in developed countries. Although statin-type drugs are currently the most effective therapeutic agents for reducing CVD risk….Evaluation of Oral Alpha-Cyclodextrin for Decreasing Serum Cholesterol.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Cardiovascular Disease | Other: Placebo Drug: Alpha cyclodextrin | Phase 2 |
What is another name for cyclodextrin?
beta-CYCLODEXTRIN
PubChem CID | 444041 |
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Structure | Find Similar Structures |
Chemical Safety | Laboratory Chemical Safety Summary (LCSS) Datasheet |
Molecular Formula | (C6H10O5)7 or C42H70O35 |
Synonyms | beta-CYCLODEXTRIN Betadex Cyclomaltoheptaose Cycloheptaglucan 7585-39-9 More… |