Which medication is used to treat vasospastic angina?

Medication Summary Nitrates and calcium channel blockers are the mainstays of medical therapy for vasospastic angina. Other agents have been tried with variable success, including endothelin antagonists such as bosentan.

Which drug is contraindicated in vasospastic angina?

Beta Blocker Use: BETA BLOCKERS are considered INEFFECTIVE, or CONTRAINDICATED for VARIANT (VASOSPASTIC) ANGINA (it may worsen such attacks by blocking some β2 receptors that produce vasodilator effects, leaving α-mediated effects unopposed (Figure 8)(Robertson et al, 1982).

Which calcium channel blocker is best for vasospasm?

Nimodipine. Nimodipine is a dihydropyridine agent that blocks voltage-gated calcium channels and has a dilatory effect on arterial smooth muscle. It is the only FDA-approved agent for vasospasm with a half-life of about 9 h [6].

Why are beta blockers contraindications to vasospastic angina?

Beta-blockers can increase coronary artery spasm and cause chest pain so they are contraindicated in these patients. Management includes cessation of smoking, avoidance of aspirin that may cause spasm, and the use of high doses of nitroglycerin and calcium antagonists.

Is Prinzmetal angina serious?

No, Prinzmetal angina isn’t fatal. Angina is a symptom, not a disease entity. However, angina indicates that there is a problem with blood flow to the heart, which can lead to heart attacks (myocardial infarction). Untreated Prinzmetal angina could also mean that you are more likely to have heart rhythm problems.

Which drug is effective in reducing Vasospasms associated with variant angina?

Calcium-channel blockers are effective for preventing coronary vasospasm. These include amlodipine (generic, Norvasc), diltiazem (generic, Cardizem, others), and long-acting nifedipine (generic, Adalat).

Why are beta-blockers contraindicated in vasospastic angina?

BETA BLOCKERS are considered INEFFECTIVE , or CONTRAINDICATED for VARIANT (VASOSPASTIC) ANGINA (it may worsen such attacks by blocking some β2 receptors that produce vasodilator effects, leaving α-mediated effects unopposed (Figure 8) (Robertson et al, 1982). See full answer to your question here.

What to do for angina attack?

Lifestyle changes recommended to treat angina include: eating fruits, vegetables, whole grains, low-fat or no-fat dairy products, and lean meat and fish Nitrates, such as nitroglycerin, are most often prescribed for angina. Nitrates prevent or reduce the intensity of angina attacks by relaxing and widening blood vessels.

Do I have Prinzmetal angina?

Prinzmetal’s angina is an older term for a type of chest pain more commonly known as a coronary artery spasm-a tightening of the muscles within the arteries of the heart. These brief, temporary spasms block blood flow to heart muscle, triggering chest pain.

How is angina pectoris prevented?

Adopting a heart-healthy lifestyle can help you keep your cholesterol and blood pressure down, keep your arteries clear, and prevent angina. Eat lots of fruits, vegetables, whole grains, and low-fat sources of protein such as nuts and fish. Exercise regularly. Maintain a healthy weight and keep diabetes under control. Quit smoking.