What is bullous pemphigoid caused by?

Bullous pemphigoid occurs when your immune system attacks a thin layer of tissue below your outer layer of skin. The reason for this abnormal immune response is unknown, although it sometimes can be triggered by taking certain medications.

What does pemphigoid rash look like?

Symptoms of pemphigoid a red rash develops before the blisters. the blisters are large and filled with fluid that’s usually clear, but may contain some blood. the blisters are thick and don’t rupture easily. the skin around the blisters may appear normal, or slightly red or dark.

Is Grover’s disease curable?

There is no cure for Grover’s disease and treatment is usually based on a person’s symptoms. Affected individuals are usually advised to avoid strenuous exercise and excessive sun exposure, as sweating and heat may induce more itchy spots.

Is pemphigoid an autoimmune disease?

Pemphigus is a rare group of autoimmune diseases. It causes blisters on the skin and mucous membranes throughout the body. It can affect the mouth, nose, throat, eyes, and genitals. Pemphigus vulgaris is the most common type of pemphigus.

What is Suprabasilar acantholysis?

Suprabasal acantholysis, a common feature of several inflammatory skin diseases, develops exclusively within the germinative cellular pool of the epidermis. The process induces repair mechanisms by proliferation of cells in the suprabasal layers in whatever conditions it occurs, except in pemphigus vulgaris.

How do you get rid of Grovers disease?

What is the pathophysiology of bullous pemphigoid?

Pemphigus and bullous pemphigoid are autoantibody-mediated blistering skin diseases. In pemphigus, keratinocytes in epidermis and mucous membranes lose cell-cell adhesion, and in pemphigoid, the basal keratinocytes lose adhesion to the basement membrane.

How do autoantibodies in pemphigus foliaceus induce blistering?

Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin. Am J Pathol. 2008;173:1628–36.

How is pemphigus differentiated from other bullous skin diseases?

The disease needs to be differentiated from bullous pemphigoid, linear IgA bullous skin disease and herpetic dermatitis. Pemphigus lesion is often limited to the oral cavity in the early stages of the disease, which renders it difficult to diagnose and distinguish from aphthous mouth ulcers and lichen planus.

What is the difference between acantholysis and blisters?

Blistering dermatitises are characterized by the presence of blisters that begin owing to acantholysis (intraepidermic blister) such as pemphigus vulgaris (PV) or owing to dermoepidermic detachment (subepidermic blister) such as bullous pemphigoid (BP). Both diseases are autoimmune pathologies chara …