What is the use of clofibrate?
Clofibrate is used to lower cholesterol and triglyceride (fat-like substances) levels in the blood. This may help prevent medical problems caused by such substances clogging the blood vessels.
What is the mechanism of action of clofibrate?
Although the exact mechanism of action has not been fully characterized, clofibrate may enhance the conversion of very-low-density lipoprotein (VLDL) to low-density lipoprotein (LDL), decreasing the production of hepatic VLDL, inhibiting cholesterol production, and increasing fecal excretion of neutral sterols.
Is clofibrate a statin?
Use of clofibrate decreased with the availability of statins for therapy of hyperlipidemia and subsequently it was withdrawn from use in 2002. Clofibrate was available previously in generic forms and under the brand name of Atromid-S as capsules of 500 mg.
Which starting material is used for synthesis of clofibrate?
Clofibrate is synthesized simply by condensation of p-chlorophenol with acetone and chloroform and the resultant acid [2-(4-Chlorophenoxy)-2-methylpropanoic acid] (I) was esterified with ethyl alcohol in the presence of catalytic amount of sulphuric acid to give clofibrate.
What is cholestyramine prescribed for?
Cholestyramine is used to lower high cholesterol levels in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels. Cholestyramine is also used to remove substances called bile acids from your body.
How does colestipol lower cholesterol?
By promoting the elimination of bile acids, colestipol forces the liver to convert more cholesterol into bile acids in order to replace the lost bile acids. This reduces the levels of cholesterol within the body. Colestipol works similarly to cholestyramine (Questran).
What type of drug is clofibrate?
Clofibrate is a lipid-lowering agent (antilipidemic) used for controlling high cholesterol (anticholesteremic) and triacylglyceride levels in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, thereby reducing VLDL levels.
What is the correct Iupac name of clofibrate?
CHEBI:3750 – clofibrate
| ChEBI Name | clofibrate |
|---|---|
| Definition | The ethyl ester of clofibric acid. |
| Stars | This entity has been manually annotated by the ChEBI Team. |
| Supplier Information | ChemicalBook:CB5774380, eMolecules:492659, MolPort-000-145-477, Selleckchem:Clofibrate(Atromid-S), ZINC000000056648 |
| Download | Molfile XML SDF |
What are the side effects of taking lovastatin?
Side Effects
- Bladder pain.
- bloody or cloudy urine.
- chest tightness.
- difficult, burning, or painful urination.
- difficulty with moving.
- frequent urge to urinate.
- joint pain or swelling.
- muscle ache, cramp, spasm, stiffness, pain, tenderness, or weakness.